Petra Bacher - IL-17 immunity and aspergillosis

Patients with impaired Th17 responses are at increased risk of mucocutaneous candidiasis but rarely at greater risk from airborne moulds. ARTE was used to analyse human T helper cell responses against 30 species commonly found in the human mycobiome. Candida albicans was the major direct inducer. However Th17 cells with cross-reactivity against Aspergillus fumigatus were selectively activated and expanded in patients with airway inflammation e.g. COPD CF asthma Th17 反应不良的患者患粘膜皮肤念珠菌病的风险增加但很少感染空气中的霉菌采用 ARTE 分析了人体辅助性 T 细胞对人体真菌组中常见的 30 个菌种的反应白色念珠菌是主要的直接诱因但是在患有气道炎症例如 COPDCF哮喘的患者中可与烟曲霉交叉反应的 Th17 细胞被选择性活化 并出现扩增,